Summary: Scientists have successfully developed a method that combines bone replacement and drugs to regenerate bone and heal severe fractures in the thighs and lower legs. The study was carried out in mice, but the scientists think this approach, when combined with different combinations, will become common in clinical settings.

Researchers from Lund University in Sweden, in collaboration with colleagues in Dresden, Germany, have successfully found a method that combines alternative bone and drugs to regenerate and heal severe fractures. weight in thighs and legs. The study, published in the scientific journal Science Advances, was conducted in mice, but they think the approach, when combined with different combinations, will become common in clinical settings.

According to Deepak Raina, orthopedic trauma expert and lead author of the study, “The drugs and materials used by us for this bone regeneration study were approved. We simply wrapped them in a newer combo. Therefore, there is no real impediment to the use of this method in clinical practice or on certain bone defects that are difficult to heal in patients. But we wanted to introduce a technique that is controllable through clinical practice and has been recently ethically approved.”

Human bone structure has an amazing ability to heal itself, but for some defects that are too large or complex, the healing process is delayed or even completely lost. This may be because the bone has suffered too much from a major trauma associated with, for example, a traffic accident, or from a tumor or infection that causes a major defect. These causes are currently being treated through bone grafting, and often from the patient’s own pelvis.

“In cases with large open wounds in the lower leg, more than 5% of broken bones will fail to heal. But with our solution, we will be able to avoid removing the bone from the pelvis, which is a huge achievement for the patient.”

There is a need to find new solutions and research teams on this, both Europe and America, are conducting research to improve bone healing in patients. Until now, the successful injectable cocktail cocktail invented by Swedish and German scientists contains three distinct ingredients: an artificial porcelain material developed in Lund, a biologically active bone protein. (rhBMP-2) and a drug, a bisphosphonate, which inhibits bone resorption.

“The bone protein we used had a negative effect in the previous study because of a secondary resorption of the young bone, as well as a few other things,” says Deepak Raina. We have successfully reduced this effect with bisphosphonates and, by slowly encapsulating the regenerative bone replacement drug, we are able to control the rate of release. In the present study of the compound, we succeeded in reducing the amount of protein by up to 6 times compared to previous attempts, and still succeeded in bone regeneration. As a result, even large fractures can heal without any complications. We believe this finding could be useful for clinical practice in the future.”

Post source: Materials provided by Lund University.

Link to the article: https://www.sciencedaily.com/releases/2021/01/210119114332.htm

Reference sources for journals:

1. Deepak Bushan Raina, Lucas-Maximilian Matuszewski, Corina Vater, Julia Bolte, Hanna Isaksson, Lars Lidgren, Magnus Tägil, Stefan Zwingenberger. A facile one-stage treatment of critical bone defects using a calcium sulfate/hydroxyapatite biomaterial providing spatiotemporal delivery of bone morphogenic protein–2 and zoledronic acid. Science Advances, 2020; 6 (48): eabc1779 DOI: 10.1126/sciadv.abc1779

Translated by: Quoc Dung

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