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[Sciencedaily] How to avoid leg amputation in diabetic patients?

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April 20, 2016

Source: Tomsk Polytechnic University (TPU)

Summary:

Scientists have developed a technique to treat diabetic feet with special insoles containing silver nanoparticles. These techniques help combat ulcers that appear on the feet in diabetics, facilitate healing and disinfect wounds, and reduce the risk of amputation.

Tomsk Polytechnic University, together with Novosibirsk and Mexican partners, is developing silver preparations that reduce the risk of infection.

“Research has shown that silver’s antibacterial properties help quickly heal diabetic foot ulcers.

Together with colleagues from Mexico, we are working to create special insoles for diabetics. The clinical trial is already underway, Professor Alexey Pestryakov, Head of the Department of Physical Chemistry and Analysis of TPU, said that in patients who used pads impregnated with silver nanoparticles, foot ulcers healed. , the risk of amputation is significantly reduced.

Foot complications in people with diabetes are one of the late and most serious complications of the disease. Due to the large amount of glucose in the blood, there is damage to the peripheral nerves, blood vessels, skin and soft tissues, bones and joints of the patient. Infections, ulcers, pus formation, etc. are remarkable symptoms.

Up to 15% of people with diabetes are at risk of developing foot ulcers. In the advanced form, it can lead to amputation.

A scientist-led team has developed pharmaceuticals based on silver nanoparticles that have a enveloping effect on viruses, bacteria and fungi. The scientists have been collaborating with their Mexican colleagues for more than 10 years.

The source:

Materials provided by Tomsk Polytechnic University (TPU).

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References:

Belén Borrego, Gema Lorenzo, Josué D. Mota-Morales, Horacio Almanza-Reyes, Francisco Mateos, Elena López-Gil, Nuria de la Losa, Vasily A. Burmistrov, Alexey N. Pestryakov, Alejandro Brun, Nina Bogdanchikova. Potential application of silver nanoparticles to control the infectivity of Rift Valley fever virus in vitro and in vivo. Nanomedicine: Nanotechnology, Biology and Medicine, 2016; 12 (5): 1185 DOI: 10.1016/j.nano.2016.01.021

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