A new analysis shows that a class of drugs widely used to treat heartburn and peptic ulcers improves blood sugar control in people with diabetes when added to conventional treatments. usually medically.

The same study found that the same class of drugs — known as proton pump inhibitors (PPIs) and including drugs like omeprazole — did not prevent diabetes in people who didn’t already have the disease.

As well as the antacid mechanism, “We know that these drugs affect several intestinal hormones that are important in glucose regulation,” Dr. Kashif Munir, told WebMD.

The doctor said, “So if someone is taking PPIs and they are in good health, it helps them realize that PPIs can also be helpful for diabetes if they are already suffering from it.”

The study was published online June 25, 2021, in the Journal of Clinical Endocrinology & Clinical Metabolism (The Journal of Clinical Endocrinology & Metabolism).

Antacids reduce two parameters of diabetes

Munir, an associate professor of endocrinology, diabetes, and nutrition at the University of Maryland School of Medicine in Baltimore, and colleagues examined the results of five studies that included nearly 250,000 people with diabetes. . The researchers did not find that the use of proton pump inhibitors reduced the risk of diabetes in this population.

But then, they reviewed seven studies involving 342 patients with diabetes to see the impact of PPIs on blood sugar control.

Overall, PPI therapy as an adjunct to standard of care was associated with an additional 0.36% reduction in glycosylated hemoglobin (HbA1c) compared with standard therapy, the report said.

Hemoglobin glycosyl is a measure of a patient’s average blood glucose levels taken over the past 2 to 3 months, and levels are 6.5% or higher on two separate tests that diagnose diabetes.

While a 0.36% reduction in A1c sounds modest, Munir notes, the FDA still considers blood sugar-lowering drugs if they reduce A1c by at least 0.3%.

Similarly, the use of PPIs in addition to standard diabetes prevention combined with an additional 10.0 milligrams per deciliter (mg/dl) of fasting blood sugar.

The researchers found that the higher the dose of PPIs, the better the blood sugar-lowering effects.

And patients with poor blood sugar control — reflected in higher A1c levels — were more effective when they took antacids than those with diabetes controlled from the start.

Impact of proton pump inhibitor antacids on blood sugar control “Should be considered when prescribing antacids to patients with diabetes,” the researchers concluded.

Munir said, “If you are one of them [mắc bệnh đái tháo đường] If you suffer from heartburn, PPIs are considered a beneficial therapy to treat both conditions with one drug.”

The source: https://www.medscape.com/viewarticle/954247

Kashif Munir, MD, associate professor of endocrinology, diabetes, and nutrition, University of Maryland School of Medicine, Baltimore.

The Journal of Clinical Endocrinology & Metabolism: “Effects of Proton Pump Inhibitors on Glycemic Control and Incident Diabetes: A Systematic Review and Meta-Analysis.”

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Translated by: Thuy Linh