INFLAMMATION – PART 02
Hello everyone, in this section we continue to analyze the characteristics of acute inflammation. Each of these features shows clinical symptoms. Start with congestion.
See also: Lecture: Inflammation (INFLAMATION) – Part 01
What is congestion?
Congestion is the primary response to acute inflammation, which occurs when damage triggers nervous action and causes the cells to release chemical mediators that cause vasodilation. This causes blood vessels to become stagnant, causing two main symptoms: redness and heat.
Why does inflammation cause edema?
Inflammation is a protein-rich fluid that exits the vessels and flows into the interstitial tissue, causing swelling and pain if it hits the nerve receptors. This helps to dilute the existing toxins in the inflammatory foci. In addition, the fluid also contains antibodies (antibodies) and fibrin to help enhance the immune effectiveness and localize inflammation.
There are two mechanisms that cause inflammation
– Increased permeability (permeability) of the vessel wall: caused by intermediate chemicals (eg, histamine, bradykinin, leukotrienes) and direct blood vessel damage
– Increased blood flow to the inflammatory drive: congestive and colloidal pressure reduction phenomenon (oncotic pressure) due to protein drainage
Therefore, one of the characteristics to distinguish inflammatory fluid is that the fluid protein will increase.
What do white blood cells penetrate into the inflammatory foci?
The main task of leukocytes is to kill the inflammatory agent, which is done in three steps:
Step 1: Margin and integration (margination and integration): The white blood cells from the blood vessels will attach to the vessel wall by attaching cell adhesion molecules (CAM) to the selectin proteins, then integrin. to cross the circuit.
Step 2: Chemostasis: The white blood cells will travel with the pseudopod to the place with the highest concentration of active chemicals, which will usually be a protein or a polypeptide chain.
Step 3: Phagocytosis: Upon arrival, white blood cells encapsulate the inflammatory agent and release highly oxidizing enzymes to digest it.
So they already know how to analyze the characteristics of acute inflammation.
Phu Duc
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